Different properties of four molecular forms of protein kinase CK2 from Saccharomyces cerevisiae.

نویسندگان

  • Katarzyna Domańska
  • Rafał Zieliński
  • Konrad Kubiński
  • Ewa Sajnaga
  • Maciej Masłyk
  • Maria Bretner
  • Ryszard Szyszka
چکیده

CK2 is a pleiotropic constitutively active serine/threonine protein kinase composed of two catalytic alpha- and two regulatory beta-subunits, whose regulation is still not well understood. It seems to play an essential role in regulation of many cellular processes. Four active forms of CK2, composed of alphaalpha'betabeta', alpha(2)betabeta', alpha'(2)betabeta', and a free alpha'-subunit were isolated from wild-type yeast and strains containing a single deletion of the catalytic subunit. Each species exhibits properties typical for CK2, but they differ in substrate specificity and sensitivity to inhibitors. This suggests that each CK2 isomer may regulate different process or may differ in the way of its regulation.

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عنوان ژورنال:
  • Acta biochimica Polonica

دوره 52 4  شماره 

صفحات  -

تاریخ انتشار 2005